Video games have become sophisticated enough to have movie-worthy (OK, maybe not all of them are) scripts and plots. I'm now far more interested in the story component of a game than the multiplayer component.
So please, use the spoiler tag when revealing any game plot details! Exceptions: you won't be spoiling anyone's gaming if you reveal that 'the princess is in another castle at the end of world 7-4 in Super Mario'; so any game that's been played to death for the last 5-10 years or more is OK.
Not a hard rule, but please be considerate.